Numerous studies have demonstrated that the uplift of the Cenozoic Tibetan Plateau (TP) and orbital cycles are important factors influencing the evolution of Asian climate on tectonic (>1 Ma) and orbital (<1 Ma) time scales, respectively. Additionally, the TP uplift on the tectonic time scales would regulate the magnitude of climate change on the orbital time scales, which might be used to explain why the Asian climate is mainly controlled by different orbital parameters in different periods and/or regions. To explore this issue, we used the Community Earth System Model Version 1.2.2 to simulate the Asian climate during the Oligocene. The simulation results show that the uplift of the TP during this period strengthened the Asian monsoon and led to an increased in precipitation, which is consistent with the results of the Asian sedimentary records. The response of precipitation in South and Southeast Asia to orbital forcing intensified with the uplift of the TP. In the early Oligocene, increased summer insolation resulted in an increase in annual precipitation in South China, but the increase magnitude is declined in the late Oligocene. In contrast, early Oligocene annual precipitation in North China was weakly influenced by orbital forcing, but annual precipitation decreased as summer insolation increased by the late Oligocene. These changes were mainly due to the uplift of the TP, which acted as a significant heating source, strengthening monsoon circulation and changing the regional atmospheric circulation. This, in turn, regulated the response of East Asian precipitation to orbital variations. Therefore, when exploring the impacts of orbital cycles on the Asian climate during the early Cenozoic, it is essential to consider the evolution of Asian paleogeography, especially the TP uplift.